Personalized Health Technologies 2020

Virtual-only conference on personalized health tools, technologies & research in and around Switzerland
When? June 29 & 30, 2020

Registration is open and free



Find all the abstracts in our abstract booklet.

Discussion platform during the event

We are using Slack in addition to the Zoom webinar setup:

Please join our conference Slack instance to follow up on topics, get support with technical problems, and a scheduled updates on the talks and abstracts.

Overview

The next steps in personalized health. This conference brings together experts from multiple disciplines to explore present and future directions in the field of personalized health technologies and translational research. The goal is to tackle challenges in chemical hit identification, lead development, molecular circuit analyses, clinical bioinformatics, and multivariate statistics, as well as their clinical application.

From patient samples to molecular read outs. Progress in the laboratory representation of clinical material has enabled novel possibilities for discovery and diagnostics with thus far unrivaled proximity to the patient. Advanced cell systems such as organoids allow for in-depth molecular profiling and functional studies as well as investigation of responses to chemical and therapeutic agents. Combined with high-throughput screening and chemical biology, empirical projects of very large scope have not only become conceivable but also present themselves with feasible turnaround time.

Integration of molecular modalities and global knowledge. The continuous development of next-generation sequencing and mass spectrometry measurements allow for high-resolution characterization of biomolecules derived from patient samples or mouse models of disease. While early challenges of storage and compute capacity have largely been addressed, present ones are the integration and combined analysis of multifaceted data, including public online resources.

Confirmed Speakers for 2020

Meromit Singer, PhD (Harvard Medical School/Dana-Farber Cancer Institute)
Assistant Professor
Department of Data Sciences, DFCI
Department of Immunology, Harvard Medical School
Caroline Uhler, PhD (ETH Zurich)
Professor, Machine Learning, Statistics and Genomics
Department of Biosystems Science and Engineering
Senthil K. Muthuswamy, PhD (Dana-Farber/Harvard Cancer Center)
Associate Professor, Medicine, Harvard Medical School
Director of Cell Biology at Cancer Center, Medicine, Beth Israel Deaconess Medical Center
Cancer Cell Biology, Member of DF/HCC program
Prashant Mali, PhD (UC San Diego)
Assistant Professor, Department of Bioengineering, UCSD
Michal Bassani, PhD (UNIL/CHUV)
Group leader Human integrated tumor immunology discovery engine (Hi-TIDe)
Department of oncology UNIL CHUV
Head of clinical mass spectrometry unit, Center of experimental therapeutics
Alessandra Curioni, MD (University Hospital Zurich)
Group leader translational oncology
Departments of Medical Oncology and Hematology
University of Zurich, Faculty of Medicine


Speakers in previous editions

Calvin Kuo (Standford University)
Professor of Medicine (Hematology)
Professor of Chemical and Systems Biology
Co-Lead, Cancer Biology Program, Stanford Cancer Center
Vice Chair for Basic and Translational Research, Department of Medicine
Olivier Elemento (Weill Cornell Medicine)
Director, Englander Institute for Precision Medicine
Associate Director, Institute for Computational Biomedicine
Co-Assistant Dean for Scientific Computing
Co-Director, WorldQuant Initiative for Quantitative Prediction
Co-Leader, Genetics, Epigenetics and Systems Biology Program, Meyer Cancer Center
Lillian L. Siu (Princess Margaret Cancer Centre)
Professor of Medicine at the University of Toronto
Director of the Phase I Program
Co-Director of the Bras and Family Drug Development Program
BMO Financial Group Chair in Precision Genomics
Nikolaus Schultz (Memorial Sloan Kettering Cancer Center)
Head of Knowledge Systems
Marie-Josée & Henry R. Kravis Center for Molecular Oncology

Audience

This conference brings together multidisciplinary experts to explore present and future challenges in the field of personalized health technologies and translational research.

We look forward to welcoming researchers, clinicians and scientists from university, industry and the public sector who are interested in the latest progress of personalized health technologies, translational research and development.

Gold Sponsor

Berkeley Lights, accelerates cell screening processes by automation and miniaturization from months to days. Scientists can now precisely manipulate, culture, assay and recover live 100s - 10.000s of single cells one by one, with a 100-fold increase in insights, 10x faster, at a fraction of the cost.

The Hirslanden Private Hospital Group operates 17 hospitals, many of which have an integrated outpatient surgery centre and an emergency department, as well as 3 outpatient clinics, 2 day case clinics, 17 radiology institutes and 4 radiotherapy institutes. It is the largest medical network in Switzerland.

Silver Sponsors

Cytiva is a global provider of technologies and services that advance and accelerate the development and manufacture of therapeutics. Our customers undertake life-saving activities ranging from fundamental biological research to developing innovative vaccines, biologic drugs, and novel cell and gene therapies.

Personalized Health and Related Technologies (PHRT) is a strategic focus area of the ETH Domain. Its goals include improving the quality of precision medicine through supporting earlier and better diagnosis as well as providing a choice of individual therapeutic strategies for patients based on their particular biological make-up and other patient-related factors.

The Fritz Gyger AG -a world leader in high speed micro solenoid valve technology- develops and produces dispensing solutions for all types of media. The Certus Flex liquid dispenser technology sets new standards in drug discovery and assay miniaturisation, enabling precise and accurate dispensing.

In over 15 years Enamine has become a global provider of Screening Compounds, Building Blocks, and Fragments for supporting a wide range of research programs conducted by pharmaceutical and biotech companies, drug discovery centers, academic institutions and other research organizations worldwide.

Bronze Sponsors

Agenda

The conference will be structured in four sessions. Find all the abstracts here.

Monday 29 June 2020
Session 1 - Immuno Oncology (Chair: Shana Sturla)
10:00 - 10:15
Welcome address by Niko Beerenwinkel, Chair of NEXUS
The session 1 keynote is scheduled for today at 15:50 (CEST).

10:15 - 10:40
Michal Bassani (CHUV)
Proteogenomics and immunopeptidomics for the development of personalized cancer immunotherapy
10:40 - 10:45
Tech Slam David Pointu (cytiva)
Explore the diversity of cancer tissue section by IF multiplexing with Cell DIVE
10:45 - 11:10
Alessandra Curioni (USZ)
Success and challenges of immune-checkpoint inhibitors for the treatment of lung cancer
Short Break

11:35 - 12:00
Rodrigo Vazquez-Lombardi (ETH Zurich)
Harnessing CRISPR-Cas9 genome editing for the functional engineering of T cell receptors with minimal cross-reactivity
Session 2 - Advanced Cell Systems (Chair: Christian Stirnimann)
13:00 - 13:25
Nicolas Broguiere (EPFL)
Reconstruction of the tumor microenvironment to improve the phenotypic stability of human colorectal cancer tumoroids
13:25 - 13:30
Tech Slam Sabrina Dällenbach (Fritz Gyger AG)
CERTUS FLEX for dispensing droplet microarrays
13:30 - 13:55
Furkan Gökçe (ETH Zurich)
Physiologically relevant drug-screening approaches to personalize leukemia treatments
13:55 - 14:20
Christian Hirt (UZH)
Discovery of alternate treatment options for pancreatic cancer using automated high-throughput screening on patient-derived organoid lines
Coffee Break

14:35 - 15:35
Senthil K. Muthuswamy (DFCC)
Tumor organoids for cancer biology and personalized medicine
15:35 - 15:50
Tech Slam Mio Muelthaler (Berkeley Lights)
Directly test individual T cell function with fewer cells
15:50 - 16:50
Meromit Singer (DFCI)
From characterization towards function: systemic aspects of T cell immunity in cancer and autoimmunity
Closing Remarks Day 1

Tuesday 30 June 2020
Session 3 - Clinical Decision Making (Chair: Gunnar Rätsch)
09:00 - 10:00
Caroline Uhler (ETH Zurich)
Causality and Multi-Domain Data Integration in the Light of Drug Repurposing for SARS-CoV-2
Coffee Break

10:15 - 10:40
Stefan Stark (ETH Zurich)
SCIM: universal single-cell matching with unpaired feature sets
10:40 - 10:45
Tech Slam Francois Curtin (PHRT)
The future of Personalized Health: Building Bridges
10:45 - 11:10
Michael Baudis (UZH)
Beacon v2 - Towards flexible use and clinical applications for a reference genomic data sharing protocol
Short Break

11:35 - 12:00
Emilie Pasche (HES-SO)
SVIP-O, the Swiss Variant Interpretation Platform for Oncology
Session 4 - Novel Therapeutics (Chair: Karl-Heinz Altmann)
13:25 - 13:50
Roger Schibli (PSI)
An academic platform for translational radiotracer development for non-invasive imaging
13:50 - 13:55
Tech Slam Andrey Tarnovsky (Enamine)
New dimension for drug discovery
13:55 - 14:20
Anna Popova (Karlsruhe Institute of Technology)
Enabling precision oncology: highly miniaturized chip-technology for testing live patient-derived cancer cells with anti-cancer compounds to reveal individual drug sensitivity and resistance
Coffee Break

14:35 - 15:35
Prashant Mali (UCSD)
Improving genome interpretation and gene therapeutics: new approaches and new challenges
Closing Remarks Day 2

Organizers

NEXUS Personalized Health Technologies: an ETH Technology Platform created to enable and accelerate the execution of translational research projects by providing key technological resources, tools and collaboration opportunities for the personalized health research community.

Niko Beerenwinkel
Full Professor of Computational Biology
Chair and Co-Founder of NEXUS Personalized Health Technologies
Group Leader at the Swiss Institute of Bioinformatics
Daniel Stekhoven
Head Clinical Bioinformatics at NEXUS Personalized Health Technologies
Group Leader at the Swiss Institute of Bioinformatics
Christian Stirnimann
Head Theragnostics Discovery at NEXUS Personalized Health Technologies
Sara Gerber
Organising Manager Personalized Health Technologies 2020

Contact

Please contact us for further information at personalizedhealth@nexus.ethz.ch

Disclaimer

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